Manufacturers of Generic Drug Eldepryl and Azilect – What You Need to Know

Manufacturers of the generic drug Eldepryl and Azilect

Eldepryl (selegiline) and Azilect (rasagiline) are both generic drugs used primarily for the treatment of Parkinson’s disease. Let’s take a closer look at the manufacturers of these two medications.

Eldepryl (selegiline)

Eldepryl is a prescription drug that contains the active ingredient selegiline. Selegiline belongs to a class of drugs known as monoamine oxidase inhibitors (MAOIs) and is used to treat the symptoms of Parkinson’s disease.

Eldepryl is manufactured by several pharmaceutical companies, including:

  1. Alvogen, Inc.
  2. Amerigen Pharmaceuticals Limited
  3. Anchen Pharmaceuticals, Inc.
  4. Aurobindo Pharma Limited
  5. Dr. Reddy’s Laboratories Limited
  6. Fresenius Kabi USA, LLC
  7. Impax Laboratories, LLC
  8. Mylan Pharmaceuticals Inc.
  9. Par Pharmaceuticals, Inc.
  10. Perrigo Company PLC

These manufacturers produce generic versions of Eldepryl, which means they contain the same active ingredient selegiline and have been proven to be bioequivalent to the brand-name medication. However, the inactive ingredients may vary between different manufacturers.

Azilect (rasagiline)

Azilect is another prescription drug used for the treatment of Parkinson’s disease. Its active ingredient is rasagiline, which belongs to a class of drugs called selective monoamine oxidase inhibitors (MAO-B inhibitors).

Just like Eldepryl, Azilect is also manufactured by several pharmaceutical companies. These companies include:

  1. Teva Pharmaceuticals USA, Inc.
  2. Accord Healthcare, Inc.
  3. Apotex Corp.
  4. Hetero USA Inc.
  5. Mylan Pharmaceuticals Inc.
  6. Prinston Pharmaceutical Inc.
  7. RedPharm Drug, Inc.
  8. Sandoz Inc.
  9. Taj Pharmaceuticals Limited

Similar to the generic versions of Eldepryl, the generic versions of Azilect also contain the same active ingredient rasagiline and are bioequivalent to the brand-name medication.

It’s important to note that the availability of generic versions may vary by country and region. Additionally, the pricing of these medications can vary between different manufacturers and pharmacies.

2. Key differences between Eldepryl (selegiline) and Azilect (rasagiline)

While both Eldepryl (selegiline) and Azilect (rasagiline) are commonly prescribed medications for Parkinson’s disease, there are several key differences between the two.

Mechanism of Action

Selegiline, the active ingredient in Eldepryl, is an irreversible inhibitor of monoamine oxidase type B (MAO-B). MAO-B is an enzyme that breaks down dopamine in the brain. By inhibiting MAO-B, selegiline increases the levels of dopamine, thereby improving the symptoms of Parkinson’s disease.

Rasagiline, the active ingredient in Azilect, also inhibits MAO-B but in a selective and reversible manner. It has a similar mechanism of action to selegiline, helping to increase dopamine levels in the brain.

Administration

Eldepryl is available as an oral tablet and an orally disintegrating tablet. The usual recommended dose for Parkinson’s disease is 5 mg taken twice daily. It is usually taken together with levodopa/carbidopa, another medication commonly prescribed for Parkinson’s disease.

Azilect, on the other hand, is available as an oral tablet and is taken once daily. The usual recommended dose is 1 mg per day. It can be taken alone as monotherapy or with other Parkinson’s disease medications.

Potential Interactions

Both Eldepryl and Azilect may interact with certain medications. They are contraindicated with non-selective MAO inhibitors, such as certain antidepressants, due to the risk of serotonin syndrome. Additionally, they may interact with other antidepressants, opioids, and sympathomimetic agents. It is important to inform your healthcare provider about all medications you are taking before starting treatment with either Eldepryl or Azilect.

Side Effects

Common side effects of Eldepryl include nausea, dry mouth, dizziness, and insomnia. Rasagiline, the active ingredient in Azilect, may cause side effects such as headache, indigestion, joint pain, and flu-like symptoms. It is important to discuss any side effects with your healthcare provider.

In conclusion, while both Eldepryl and Azilect are effective medications for Parkinson’s disease, they have different mechanisms of action, dosing regimens, and potential interactions. It is important to work closely with your healthcare provider to determine which medication is best suited for your individual needs.

3. Comparison of Eldepryl and Azilect

Eldepryl (selegiline hydrochloride) and Azilect (rasagiline mesylate) are both medications used in the treatment of Parkinson’s disease. Although they belong to the same class of drugs called monoamine oxidase inhibitors (MAOIs), there are some differences between the two.

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Indications and Uses

Eldepryl is primarily used to improve the symptoms of Parkinson’s disease by increasing the levels of certain chemicals in the brain. It is often prescribed in combination with other medications, such as levodopa, to effectively manage the motor symptoms of the disease. On the other hand, Azilect is indicated for the treatment of Parkinson’s disease as a monotherapy, meaning it can be used alone without the need for additional medications.

Pharmacology

Both Eldepryl and Azilect work by inhibiting the enzyme monoamine oxidase-B (MAO-B), which is responsible for the breakdown of dopamine in the brain. By inhibiting this enzyme, both drugs help to increase the levels of dopamine, a neurotransmitter that is deficient in Parkinson’s disease.

Dosage and Administration

The recommended starting dose for Eldepryl is 5 mg twice daily, which can be increased up to a maximum of 10 mg twice daily. It is important to take Eldepryl with food to enhance its absorption. Azilect, on the other hand, is usually taken once daily at a recommended dose of 1 mg. It can be taken with or without food.

Side Effects

Both Eldepryl and Azilect may cause similar side effects, including nausea, headache, insomnia, dizziness, and dry mouth. However, Eldepryl may also cause a potentially dangerous interaction with certain foods and medications, leading to a sudden increase in blood pressure. This interaction is known as the “cheese effect” and can be avoided by following a low-tyramine diet.

Cost

Eldepryl, being a generic medication, is generally more affordable than Azilect, which is a brand-name drug. The average monthly cost of Eldepryl is about $50, while Azilect can cost around $400 per month.

Overall, both Eldepryl and Azilect are effective in the treatment of Parkinson’s disease. The choice between the two largely depends on individual patient factors such as the presence of other medical conditions, drug interactions, and affordability. It is important to consult with a healthcare professional to determine the most appropriate medication for each individual.

4. Comparison of Eldepryl and Azilect

Both Eldepryl (selegiline hydrochloride) and Azilect (rasagiline) are medications used to treat Parkinson’s disease. While they share similarities, they also have differences that may influence a healthcare provider’s decision when selecting the most appropriate medication for a patient.

Here is a comparison of Eldepryl and Azilect based on various factors:

1. Active Ingredient

– Eldepryl contains selegiline hydrochloride as its active ingredient.

– Azilect contains rasagiline mesylate as its active ingredient.

2. Mechanism of Action

– Both Eldepryl and Azilect are selective, irreversible monoamine oxidase-B (MAO-B) inhibitors. They help increase the levels of dopamine in the brain by blocking the enzyme responsible for its breakdown.

3. Dosage Forms and Strengths

– Eldepryl is available in tablet form with a strength of 5 mg.

– Azilect is available in tablet form with strengths of 0.5 mg and 1 mg.

4. Administration

– Eldepryl is typically taken orally, usually once or twice a day.

– Azilect is also taken orally, once daily.

5. Drug Interactions

– Both medications have potential drug interactions with certain antidepressants, narcotic pain medications, and other MAO inhibitors. It is essential to consult a healthcare provider or pharmacist before starting these medications.

6. Side Effects

– Common side effects associated with Eldepryl include nausea, dizziness, dry mouth, and headache.

– Common side effects associated with Azilect include headache, joint pain, indigestion, and depression.

7. Cost

– The cost of Eldepryl may vary depending on factors such as insurance coverage and pharmacy. The average price for a 30-day supply of Eldepryl 5 mg tablets is approximately $XX.XX.

– The cost of Azilect may also vary. On average, a 30-day supply of Azilect 0.5 mg tablets costs around $XX.XX.

Summary

Both Eldepryl and Azilect are effective medications for treating Parkinson’s disease. The choice between them may depend on factors such as individual patient characteristics, cost, and potential drug interactions. Healthcare providers should carefully evaluate each patient’s specific needs before deciding which medication to prescribe.

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5. Comparison of Eldepryl and Azilect

Active ingredient

Eldepryl and Azilect both contain the active ingredient selegiline. Selegiline is a selective, irreversible inhibitor of monoamine oxidase (MAO) type B, which is an enzyme that breaks down dopamine in the brain.

Indications

Eldepryl is primarily used in the treatment of Parkinson’s disease. It is prescribed as an adjunctive therapy in patients already receiving levodopa/carbidopa. Azilect, on the other hand, is approved for the treatment of Parkinson’s disease as a monotherapy in the early stages, as well as an adjunctive treatment in later stages with levodopa.

Administration

Eldepryl is available in tablet form, taken orally. The usual dose is 5 mg once or twice daily, depending on the patient’s age and other medications they may be taking. Azilect is also available in tablet form, taken orally. The recommended dosage is 1 mg once daily.

Side effects

Both Eldepryl and Azilect may cause side effects. The most common side effects include dizziness, nausea, headache, and insomnia. In rare cases, they may also cause hallucinations, confusion, or hypertensive crisis. It is important to consult a healthcare professional if any side effects are experienced.

Cost comparison

When it comes to cost, Eldepryl is generally cheaper than Azilect. On average, a month’s supply of Eldepryl (5 mg tablets) can cost around $XX.XX. In contrast, a month’s supply of Azilect (1 mg tablets) can cost around $XX.XX. Prices may vary depending on the pharmacy and location.

Conclusion

Both Eldepryl and Azilect are effective medications used in the treatment of Parkinson’s disease. While they share the same active ingredient, there are differences in their indications, dosage, and cost. It is important to consult a healthcare professional to determine which medication is most suitable based on individual needs and medical history.


The benefits of selegiline for the treatment of Parkinson’s disease

Introduction

Selegiline is a generic drug that is commonly used in the treatment of Parkinson’s disease. It belongs to a class of medications known as monoamine oxidase inhibitors (MAOIs) and is primarily used to improve the symptoms of motor dysfunction associated with Parkinson’s disease. This article will explore the benefits of selegiline in the management of Parkinson’s disease, highlighting its effects on motor symptoms, disease progression, and overall quality of life.

Motor Symptom Improvement

One of the primary benefits of selegiline in the treatment of Parkinson’s disease is its ability to improve motor symptoms. It works by inhibiting the enzyme monoamine oxidase-B (MAO-B), which is responsible for the breakdown of dopamine in the brain. By inhibiting MAO-B, selegiline helps to increase the levels of dopamine, a neurotransmitter that is crucial for the proper functioning of the motor system.
Studies have shown that selegiline can significantly reduce motor symptoms such as tremors, rigidity, and bradykinesia (slowness of movement). In a clinical trial involving patients with early-stage Parkinson’s disease, selegiline was found to improve motor function and reduce disability when compared to a placebo. This improvement in motor symptoms can have a significant impact on the daily lives of individuals with Parkinson’s disease, enabling them to perform activities of daily living more easily and independently.

Disease Progression

In addition to improving motor symptoms, selegiline has also been found to potentially slow down the progression of Parkinson’s disease. Parkinson’s disease is characterized by the degeneration of dopaminergic neurons in the brain, leading to a decline in dopamine levels. By inhibiting MAO-B and increasing dopamine levels, selegiline may help to protect the remaining dopaminergic neurons from further damage.
A study conducted on patients with early Parkinson’s disease found that selegiline significantly delayed the need for levodopa therapy, a medication used to replace dopamine in the brain. This delay in initiating levodopa treatment is significant because levodopa can cause side effects and complications with long-term use. By postponing the need for levodopa, selegiline can potentially improve the long-term management of Parkinson’s disease and reduce the risk of levodopa-related complications.

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Quality of Life

The improvement in motor symptoms and potential disease-modifying effects of selegiline can greatly impact the overall quality of life for individuals with Parkinson’s disease. By reducing motor symptoms, selegiline helps to improve mobility, balance, and coordination, allowing individuals to engage in activities that were previously challenging or impossible.
In addition, selegiline’s potential to delay the need for levodopa therapy can have a positive impact on quality of life. Levodopa therapy can cause side effects such as dyskinesia (involuntary movements) and fluctuations in motor function. By postponing the initiation of levodopa, selegiline may help to minimize these side effects and complications, resulting in a better quality of life for individuals with Parkinson’s disease.

Conclusion

Selegiline is a valuable medication in the treatment of Parkinson’s disease, providing numerous benefits for individuals with this neurodegenerative disorder. Its ability to improve motor symptoms, potentially slow down disease progression, and enhance overall quality of life makes it an important component of Parkinson’s disease management. Further research and clinical trials will continue to explore the full potential of selegiline in the treatment of Parkinson’s disease and its impact on patient outcomes.

7. Comparing Eldepryl and Azilect: Which one is better?

When it comes to treating Parkinson’s disease, two commonly prescribed drugs are Eldepryl (selegiline) and Azilect (rasagiline). Both medications belong to a class of drugs called MAO-B inhibitors, which work by increasing the levels of certain chemicals in the brain that are associated with Parkinson’s disease.

While both Eldepryl and Azilect are effective in managing the symptoms of Parkinson’s disease, there are some differences between the two that may influence the choice of treatment. Let’s take a closer look at these differences:

1. Active Ingredient:

  • Eldepryl: The active ingredient in Eldepryl is selegiline hydrochloride.
  • Azilect: The active ingredient in Azilect is rasagiline mesylate.

2. Dosage:

Eldepryl comes in the form of tablets or capsules, with different strengths available. The usual recommended starting dose for Eldepryl is 5 mg taken twice a day. However, the dosage may vary depending on the individual’s response to the medication.

Azilect also comes in the form of tablets, with different strengths available. The usual recommended starting dose for Azilect is 1 mg taken once a day. As with Eldepryl, the dosage may be adjusted based on the individual’s needs.

3. Administration:

Eldepryl is typically taken orally, with or without food. It is important to follow the instructions provided by the healthcare professional regarding the timing and frequency of the dose.

Azilect is also taken orally, usually once a day. It can be taken with or without food, depending on the individual’s preference.

4. Interactions:

Both Eldepryl and Azilect may interact with certain medications, herbal supplements, and foods, potentially leading to severe side effects. It is crucial to inform the healthcare professional about all other medications or supplements being taken to avoid any harmful interactions.

5. Side Effects:

While Eldepryl and Azilect are generally well-tolerated, they may still cause side effects in some individuals. Common side effects of both drugs include headache, nausea, and dizziness. However, the specific side effects and their severity may vary from person to person.

6. Cost:

When it comes to the cost of medication, Eldepryl is generally more affordable compared to Azilect. The price of Eldepryl can range from approximately $XX to $XX per month, depending on the dosage and the location of purchase.

On the other hand, Azilect is a brand-name drug and tends to be more expensive. The price of Azilect can range from approximately $XX to $XX per month.

Conclusion:

Both Eldepryl and Azilect are effective drugs for managing Parkinson’s disease. The choice between the two medications may depend on factors such as individual response, convenience of dosing, potential interactions, and cost. It is essential to consult with a healthcare professional to determine the most suitable treatment option.

Sources:

  1. National Center for Biotechnology Information (NCBI)
  2. U.S. Food and Drug Administration (FDA)
  3. Mayo Clinic
  4. Mayo Clinic

Category: Selegiline | Tags: Eldepryl, Selegiline